Research Category
Psychedelics & Consciousness
Clinical and mechanistic research on psychedelic medicine, music in therapy, neurotechnology, and theories of altered states.
Papers in this category
Trial of Psilocybin versus Escitalopram for Depression
2021 · New England Journal of MedicineCarhart-Harris et al.
Head-to-head Phase 2 trial comparing psilocybin-assisted therapy with a standard SSRI in moderate-to-severe depression.
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression
2022 · New England Journal of MedicineGoodwin et al.
Multi-site dose-finding Phase 2b trial of a single psilocybin dose in treatment-resistant depression.
MDMA-Assisted Therapy for Severe PTSD: A Phase 3 Randomized Trial
2021 · Nature MedicineMitchell et al.
First Phase 3 RCT of MDMA-assisted therapy for post-traumatic stress disorder.
REBUS and the Anarchic Brain
2019 · Pharmacological ReviewsCarhart-Harris, Friston
Theoretical synthesis proposing that psychedelics work by relaxing high-level priors in a hierarchical predictive brain.
Sustained Rescue of Prefrontal Circuit Dysfunction by Antidepressant-Induced Spine Formation
2019 · ScienceModa-Sava et al.
Two-photon imaging in mice showing rapid dendritic spine formation after ketamine and its causal role in sustained behavioral rescue.
The Hidden Therapist: Evidence for a Central Role of Music in Psychedelic Therapy
2018 · PsychopharmacologyKaelen et al.
Demonstrated that the strength of patients' emotional response to music during psilocybin sessions predicts clinical outcome at follow-up.
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